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Comprehensive RCTs are needed to establish optimal dosing regimens, evaluate long-term safety profiles, and determine EGCGs effectiveness across different disease stages and patient populations [100]

These alterations in the composition or quantity of the NFB dimer have been found to alter downstream target gene expression, contributing, in some cells, to increased expression of pro-inflammatory genes and a pro-apoptotic environment (170, 197, 275)

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Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents