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however, excessive ROS impair NFAT activity (65)

For example, the tumor suppressor p53 and the nuclear factor erythroid 2-related factor 2 (Nrf2) have been shown to modulate ferroptotic cell death through their effects on lipid peroxidation and antioxidant defense

Nutrients are created in a lab, yes, but they are grown alongside their natural biological matrix and naturally occurring cofactors, as opposed to being 100% isolated synthetic compounds