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Description

Finally, sinigrin was lead to falling the total GSH level in normal mice (Figure 5B)

Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L

Blood 78(Suppl 1):332a, 1991

As the ER lacks glutathione reductase activity, GSSG must be exported to the cytosol by SLC33A1 to maintain redox homeostasis

Through the Fenton reaction, H 2 O 2 interacts with iron ions to produce highly reactive hydroxyl radicals ( OH), which can damage biomolecules including proteins, lipids, and DNA, thereby impairing cellular functions and leading to cell death [114]