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12, fluorescence image analysis demonstrated that D-CuP achieved enhanced cellular internalization

By disrupting the FOXO4-p53 interaction, FOXO4-DRI, a specific FOXO4 blocker, selectively induced p53 nuclear exclusion and apoptosis in senescent Leydig cells

The SI 50 values of CPP-CAND showed comparable efficacy with FOXO4-DRI (Figure

By binding to 3-UTRs of target transcripts, miRNAs can promote RNA degradation or inhibit translation and have been shown to be deregulated in various human diseases [60, 61]

Most DAT inhibitors have the propensity to bind either in the outward-open or the substrate-occluded states of DAT (Table 1)