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Gut microbiota dysbiosis contributes to the development of chronic obstructive pulmonary disease

Cancer Epidemiol Biomarkers Prev (2006) 15:176577

The lack of a standardized normalization method in microarray techniques, along with the poor correlation between altered miRNA expression profiles and their functionality in cancer as shown in functional assays, necessitates a more precise method to link miRNA with cancer prognosis (180, 181)