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Exacerbated cognitive decline at this stage is coupled with increased amyloid infiltration into multiple brain regions including the medial temporal lobe, entorhinal cortex, hippocampus, cingulate gyrus, amygdala, caudate, putamen, claustrum, thalamus, hypothalamus, and white matter, and NFTs spread to the amygdala, hippocampus, and thalamus (Koychev et al., 2020)

Acknowledgements These studies were funded by grants from the Waltham Foundation and from Purina Nestle

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J Pharmacol Exp Ther 250: 11321140