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If subcutaneous administration isn't feasible for the research model, consider encapsulation technologies or absorption enhancers for MOTS-c, though published data on oral MOTS-c efficacy remains limited compared to injectable protocols

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Studies have shown that when NNMTi is combined with a lowcalorie diet, the rate of body weight loss in obese mice is significantly faster than in either singleintervention group, with more pronounced reduction of adipose tissue and greater improvement in insulin sensitivity and hepatic metabolism

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Patients carrying two fully functional alleles are extensive metabolizers and those carrying two loss-of-function alleles are poor metabolizers