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Otherwise, the two cleaved ends will rotate freely and massively disturb the topology and functions of the DNA

doi:10.1016/j.cca.2010.08.022 Mahajan SK, Aundhakar SC

GSTP1 Of the trio involved in the above-mentioned signalosome, high GSTP1 expression levels have in fact been reported in diverse human malignancies including breast, colon and ovarian cancer, and an involvement of GSTP1 in tumorigenesis and drug resistance in general has long been recognized [53, 54]