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Alternatively, there are immunotherapies directed at surface antigens specifically upregulated in senescent cells (seno-antigens), including chimeric antigen receptor (CAR) therapies and senolytic vaccines

10.1016/j.cell.2019.03.032 Cell 7 AnthonymuthuT

Lancet 376 , 11471154 (2010)

If the immune cell is not responsive (e.g., proliferates or produces cytokines), it has become tolerant and the cytokines have not prevented tolerance induction