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Active individuals, particularly those in Pakistans urban training environments with limited daily sun exposure, commonly have suboptimal Vitamin D levels

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This impairment alters downstream AKT1 effectors including GSK3, FOXO, and mTOR, which are implicated in increased susceptibility to oxidative stress and neuronal death

Bell D, Hanna EY , Agaimy A, Weissferdt A

Scientific data and sources Research summary Level of evidence Preliminary Number of included studies: 42 16 studies 10 studies 9 studies 4 studies 2 studies 1 study Final comment: Epitalon and thymulin are peptides with promising neuroprotective, immunomodulatory, and anti-cancer potential, but most available data come from animal studies and in vitro models