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The frequency of B12 shots can vary depending on your needs

Severe B12 deficiency

Subcutaneous B12 Injection Locations The 3 Most Common B12 Injection Sites The Lower Abdomen This is one of the most common subcutaneous vitamin B12 injection sites and is to be administered at or under the level of the belly button

After first entry, an opened repeated-entry vial is generally dated and discarded within 28 days unless the manufacturer states another period.

Long-term use of metformin, a drug commonly prescribed for type 2 diabetes, is strongly associated with vitamin B12 deficiency and lower folic acid levels as it can block absorption, which may lead to increased homocysteine levels and risk for cardiovascular disease