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3D brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), replicate the cytoarchitectural complexity of the human brain and offer unprecedented opportunities to investigate disease pathogenesis

Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma

NaBPC157 In addition to a decrease of the otherwise raised blood pressure values, NaBPC157 also caused a marked attenuation or even abolition of the lesions and disturbances normally appearing in the various organs which were (after three weeks of an increased salt diet in the controls): very severe hyaline degeneration with prominent parenhymaous hemorrhages, degeneration of the arterial walls, vacuolisation of the cells in the heart, severe congestion (specifically medullar) in the adrenals, severe congestion, parenhymatous hemorrhage with hematuria in kidney and hemosiderosis and erythrocytophagia in the spleen

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FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss