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J Orthop Sports Phys Ther

Cochrane Database Syst Rev 2010(7) Sugiura H, Yoshida T, Tsuchiya K, Mitobe M, Nishimura S, Shirota S, Akiba T, Nihei H (2005) Klotho reduces apoptosis in experimental ischaemic acute renal failure

YZH, YH, and HL analyzed the results

The UCP2/SIRT3/PGC-1 signaling axis, activated by matrine, plays an important role in limiting oxidative damage by decreasing mtROS production, inhibiting ferroptosis, and preserving mitochondrial function while also implicating peroxisomal metabolism in redox homeostasis (77)