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Maintenance of Fe-S clusters is antagonistic to survival under cystine starvation To determine if the GSH-dependent maintenance of Fe-S protein function plays a contributing role to ferroptosis in NSCLC, we evaluated cell viability under cystine starvation in response to the disruption of Fe-S cluster homeostasis

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At 33 ns, it was within the active site, and it moved to an adjacent pocket at 75 ns, where it was stabilized until 100 ns