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Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Carethers J.M

197 It strengthens intestinal barrier integrity, regulates microbial metabolic activity, suppresses LPS-TLR4-mediated pro-inflammatory signaling, and coordinates FXR- and TGR5-dependent metabolicinflammatory pathways, forming a protective network across metabolic, immune, and barrier functions