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In db/db mice, dapagliflozin reshapes the gut microbiota and redirects tryptophan metabolism toward increased L-tryptophanderived metabolites, leading to augmented GLP-1 production, higher circulating GLP-1 and C-peptide levels, and expansion of -cell mass via enhanced proliferation

25%), resulting in a twofold increase in LC3-II/LC3-I ratio

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Long-term use of tesamorelin requires medical supervision and periodic evaluation

pubmed.ncbi.nlm.nih.gov/295