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When glutathione concentration is reduced, -glutatmylcysteine formation increases and this dipeptide is converted to pyroglutamic acid in the plasma

AHR/ROS-mediated mitochondria apoptosis contributes to benzo[a]pyrene-induced heart defects and the protective effects of resveratrol

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Once complexed by haem-targeting proteins or xenosiderophores, a set of TonB-dependent transporters (TBDTs) are required to transport the haem/iron into the periplasmic space, followed by transport across the inner membrane by ATP-binding cassette (ABC) transporters (Sgheiza et al., 2017)

This dynamic approach ensures optimal detoxification results while addressing individual challenges