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Int 2021 , 7880448 (2021)

Clin Pharmacol Ther 41(6):661665 Sun H, Tong Z, Fang Y, Jiang B, Liang P, Tang Y, Xiao X (2018) Nucleolin protects against doxorubicin-induced cardiotoxicity via upregulating microRNA-21

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This framework established a long-standing, strictly neuron-centric interpretation of brain function, in which synapses and neuronal circuits were regarded as the exclusive substrates of cognition, behavior, and neuropathology, while glial cells were erroneously sidelined, commonly described as passive supportive or cementing elements, reflecting the entrenched view that their role was ancillary to neuronal activity rather than mechanistically relevant to CNS function