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In laboratory settings, it is often used to observe how signaling interactions influence circadian rhythm coordination, stress-response patterns, and downstream neurochemical pathways

Arch Med Res 31:415421 Pellicano R, Smedile A, Ponzetto A, Berrutti M, Astegiano M, Saracco G, De Angelis C, Repici A, Morgando A, Abate ML, Fagoonee S, Rizzetto M (2005) How accurate is the culture of Helicobacter pylori in a clinical setting

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Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes