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In the context of AD, CR or intermittent fasting independently has been shown to promote cognitive function and protect from worsening AD pathology in animal models of AD 4,5,6,7,8,45,46,52,53

Acknowledgments We gratefully appreciate the partial financial support from Zagazig University (Zagazig, Egypt) to A

[DOI] [PubMed] [Google Scholar] 77.Zhou S.-Y., Guo Z.-N., Yang Y., Qu Y., Jin H

The MYC oncogene cooperates with sterol-regulated element-binding protein to regulate lipogenesis essential for neoplastic growth

319,320 Although there are not the evidence showing the effect of Trx on HDAC2, we suppose that Trx may increase HDAC2 activity by regulating cellular redox signalling, and we would like to prove this attractive hypothesis in our next studies