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Previous in vivo human data have shown that the plasma concentrations of APR-246 in the 12 h following its intravenous administration range from 50 to 500 mM, suggesting that concentrations above 50 mM are suitable for in vitro studies of the early effects of APR-246

Heterogeneity was negligible ( I 2 =0%)

The clinical manifestations of neurological Gaucher disease vary by subtype and manifest different symptoms 123

however, these expressions were not significant when compared to the control

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