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Importantly, the observed oxidative damage and mitochondrial impairment following GCLC knockdown were reproduced across multiple assays and time points, reinforcing its critical role in redox regulation and cellular viability [31,32,33]

Interestingly, administering 2-AR blockers coupled with CAR-T would also prevent PKA-dependent inhibition of ZAP70 phosphorylation, thereby boosting T cell activation, co-stimulation, and cytotoxicity [123]

The human liver cancer cell lines SK-Hep-1 (ATCC, #HTB-52) and Huh-7 (KCLB, Seoul, Korea, #60104), and the HEK293T cell line (ATCC, #CRL-3216) were cultured in DMEM containing 10% FBS and 1% P/S

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To protect itself, the pea-size lens has one of the highest concentrations of glutathione found anywhere in the body