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N Engl J Med (2010) 362:387401

Epstein ACR, Gleadle JM, McNeill LA, Hewitson KS, ORourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ (2001) C

Glutathione in particular has very low oral bioavailability versus near-complete IV bioavailability

The diversity and complexity of epigenetic modifications in organisms provide an essential foundation for the regulation of gene expression and cellular functions

Impairment of the structure and function of podocytes, renal tubular epithelial cells, and glomerular mesangial cells is central to the pathogenesis of DKD