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Because geriatric patients are more likely to have decreased renal function, assess renal function prior to fondaparinux sodium administration [see Contraindications (4), Warnings and Precautions (5.3), and Clinical Pharmacology (12.4)]

Some report moderate benefits

Daratumumab is approved as monotherapy and in combination with IMiD drugs (i.e., lenalidomide or pomalidomide based on the POLLUX, EQUULEUS, and APOLLO trials) or PIs (i.e., bortezomib or carfilzomib based on the CASTOR and CANDOR trials), plus dexamethasone for RRMM patients

Treatment also normalised IgG3/IgG and IgG2b/IgG ratios altered in GLI mice