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Bristol Myers Squibbs Sotyktu (deucravacitinib), one of several treatments for psoriasis approved in 2022, is the first drug to include deuterium from its inception

Diabetologia 50, 840849.10.1007/s00125-006-0522-y 13 DinisT

The therapeutic potential of targeting the SIRT1/Nrf2/HO-1/GPX4 pathway is further supported by research indicating that edaravone, a widely used anesthetic, mitigates depression and anxiety by inhibiting ferroptosis through this pathway (Shen et al., 1826)