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While some screens show direct mechanistic links to increased carcinogen-induced cytotoxicity [352,353,354], others report associative findings where gene perturbations correlate with altered stress responses without definitive causal proof [355,356]

SSADH: succinate semialdehyde dehydrogenase

Enzymatic activity was calculated after subtracting absorbance decay obtained from buffer without cell lysates by using NADPH extinction coefficient of 6220/M/cm and by normalizing to total protein content 63

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This dual push-pull is why the IGF-1Akt axis is considered a master regulator of muscle mass, although its exact role in the adult muscle response to mechanical load is, by the authors own account, less clearly defined than its role in development and regeneration