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EAAT2 is responsible for greater than 90% of glutamate transport into crude synaptosomes 14 and is the predominant glutamate transporter in the brain, except for some regions, including the cerebellum, circumventricular organs and retina, where EAAT1 is the major transporter

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b , A cross-cohort meta-analysis of the association (linear regression) between the CognitionBrain, Brain, and Conventional age gaps versus Alzheimers disease (with AD n = 1,441, without n = 2,052)

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Hormone testing is helpful-- especially for pituitary functions that affect stress hormones, sex hormones, fluid balance, and prolactin release ("post-traumatic stalk syndrome")-- and additional labs can further help identify the extent and severity of neural injury as well as the potential for progression to cognitive impairment or dementia (including tests such as phosphorylated tau protein, neuron-specific enolase, 14-3-3 protein, neurofilament light-chain, amyloid 42/40 ratio, GFAP, ApoE4, etc.)