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If side effects are troublesome, dose adjustments or discontinuation may be considered

This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

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The Q module mass error tolerance was set to 20.0 ppm and the retention time shift tolerance was set to 2.5 min

Erdman J, Oria M, Pillsbury L, editors