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10.1016/j.chom.2018.05.012 106

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Increased concentrations of asymmetric dimethyl L-arginine (ADMA) in cultured endothelial cells or in patients with endothelial dysfunction are associated with increased ROS production

Three metabolic pathways are believed to play roles in this detoxification process: carboxylesterases, monooxygenases and glutathione S-transferases [6]