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Preclinical animal studies, in vitro mechanistic investigations, and human clinical studies were eligible

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Of note, ferroptosis likely contributes to unbalanced myeloid/lymphoid lineage differentiation of long-term HSCs via cholesterol-mediated promotion of ferroptosis resistance in a SLC38A9mTOR axis-dependent fashion in a murine model of hypercholesterolemia

This stabilizing effect is seen even in the case of wild type DRI-peptides in the hybrid fibrils

Anecdotally reported side effects include nausea, headache, dizziness, and injection-site reactions for BPC-157, and mild fatigue for TB-500