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Antioxid Redox Signal 21:13051326 Copley SD, Dhillon JK (2002) Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes

Activation of IGF-IR/IRS complex also recruits and stimulates the PI3K, which converts PIP2 to PIP3 in the membrane to recruit Akt and associated proteins PDK 1/2, leading to Akt phosphorylation and activation