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24 CornutiS.ChenS.LuporiL.FinamoreF.CarliF.SamadM.et al (2023)

The 2023 international PCOS guideline does not assign letter-grade tiers to supplements, so this column is our editorial synthesis rather than a guideline grade

In a recently published study, recessive mutation in IARS was validated as a novel monogenic cause of IBD, which caused persistent pancolitis and resistantance to mesalazine, corticosteroids, azathioprine, sirolimus and anti-TNF (adalimumab) therapeutics ( Conclusion Astronomical amounts of research funding and efforts have been invested into the non-catalytic role of ARSs in various kinds of diseases