glutathione depletion paracetamol overdose Full article: Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro Paracetamol metabolism. | Download Scientific

Curr Opin Nephrol Hypertens 1998

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2.4 Glutaminolysis Glutaminolysis plays a pivotal role in GBM metabolism by supporting fatty acid synthesis by producing a flux of NADPH (a reduced cofactor) via malic enzyme activity, so much so that it appears to provide an abundance of NADPH for other anabolic processes such as nucleotide production on top of primarily lipid synthesis (68)

11a, b), indicating that exogenous GSH is important for rapid cell growth, but not for survival

(2) is the I 390 / I 490 ratio for NERNST under any given condition, with the subscripts red and ox indicating minimal and maximal R values measured with completely reduced and oxidized NERNST, respectively