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As previously mentioned, the antioxidant activity of VIC is closely related to its chemical properties

Oxidative stress occurs due to excessive reactive oxygen species (ROS) paired with inadequate levels of antioxidants, in particular glutathione [3]

proposed that renal tubular damage and fibrosis in db/db mice were associated with elevated levels of HIF-1 and HO-1, which led to iron accumulation in renal tubules by downregulation of ferritin

At the present level of our knowledge, it is safe to conclude that the orobuccal route can be used for treatment of hyperpigmentation with glutathione GSH at a dose of 10040050 mg per day for periods of between 10 and 12 weeks, depending upon indication, and it is hoped the treatment can be repeated to maintain effect