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To mitigate confounding from genetic differences, we created isogenic primitive and differentiated cell cultures then compared their pyrimidine synthesis programmes

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It also systematically describes regulatory mechanisms involving lipid peroxidation, intracellular antioxidant levels, ubiquitination of Nrf2, and expression of FSP1 and GPX4

Its mechanism involves activating the AMPK/SIRT1 pathways and suppressing lipogenic regulators like PPAR and SREBP-1c, highlighting its potential as a therapeutic candidate for NAFLD (96)

Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis