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Cyclic peptides such as simplicilliumtide J and aspergillipeptide D further extend this antiviral repertoire, effectively suppressing multiple HSV-1 strains, including acyclovir-resistant isolates [129,130]

Difficult-to-treat AIH (DTT-AIH) refers to cases where the standard first-line treatment is ineffective, poorly tolerated, or leads to frequent relapses

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This led to the FDA approval of L-glutamine as a treatment in 2017, making it the second drug approved to treat sickle cell disease after hydroxyurea (Minniti, 2018) (Figure 1)

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