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Fushimi K, Sasaki S, Marumo F

Tolerability (animal only): Reported as well tolerated in limited rodent studies an animal observation, not a human safety finding

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212 Additionally, TFEB can drive mitochondrial biogenesis independently of PGC-1 by upregulating NRF1/2 and transcription factor A (TFAM), leading to increased mtDNA synthesis

So too does pantothenate (vitamin B 5 ), the precursor to coenzyme A, as it cannot be synthesized by the parasite de novo , and it is also essential for parasite growth (Saliba et al., 1998)