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Tissue-related signaling pathways

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

While these results suggest a putative role for these neuroactive molecules as diagnostic biomarkers in PD, the employed HPLC approach did not allow us to investigate the global metabolic context on which these specific biochemical signatures are grounded