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After 3 h, the medium was removed and replaced with medium as follows: HUVEC and HDMEC were cultured in endothelial cell basal medium supplemented with 2% (HUVEC) or 1% (HDMEC) FCS, and 90 g ml 1 heparin, with or without hHGF or dimeric macrocycle

2.3 A therapeutic potential of the use of A1AT The most appropriate in vivo model to understand the anti-inflammatory activity of A1AT administration is enzyme deficiency (A1ATD) condition itself

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The Journal of Clinical Endocrinology & Metabolism 106 (6), 15531565 (2021) Chen, Y.-Y., Wu, T.-T., Ho, C.-Y., Yeh, T.-C., Sun, G.-C., Kung, Y.-H., et al.: Dapagliflozin prevents NOX- and SGLT2-Dependent oxidative stress in lens cells exposed to Fructose-Induced diabetes mellitus

(d) Ferroptosis-targeted therapeutic strategies and future perspectives, summarizing current ferroptosis-directed interventions that encompass pharmacological agents, gene therapy, and cell-based treatments, and examining both the challenges and opportunities of their clinical translation