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They concluded that no men experienced a change in semen parameters but their hormone levels rose during the treatment

they are specific tools for specific jobs

They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)

Their expertise ought to inform any reform efforts

Short Answer: DSIP is often marketed for stress reduction and cortisol regulation, but human studies have not shown clear or reliable anxiety- or cortisol-lowering effects