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Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

Oxidative modifications of lipids, proteins, and DNA are induced by mixtures of ascorbic acid and copper or iron for decades [24, 25], contributing to oxidative damage formation by reducing ferric Fe 3+ to ferrous Fe 2+ ions (and Cu 2+ to Cu + ), which in turn can reduce hydrogen peroxide (H 2 O 2 ) to hydroxyl radicals

Antioxidants are REQUIRED to prevent excess free radicals which lead to oxidative stress Free Radicals & Oxidative Stress What are free radicals and oxidative stress