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Chem Res Toxicol 36(6):900915 Xia C et al (2024) Cysteine and homocysteine can be exploited by GPX4 in ferroptosis inhibition independent of GSH synthesis

Li et al., 2024b

Under his leadership, Childrens Hospital of Pittsburgh has been one of the fastest growing pediatric research programs in the nation, with a sixfold increase in NIH funding and the hiring of more than 300 new medical faculty members

Nrf2 can then translocate to the nucleus and bind to the antioxidant response element (ARE) located in the promoters of genes coding for antioxidant/detoxifying enzymes and scavengers

Current efforts span a wide range of strategiesfrom structural optimization and target-specific drug design to the development of advanced delivery platforms