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However, MPLA-treated NOX2 KO mice exhibited approximately 10-fold higher bacterial burden compared to WT mice treated with MPLA, indicating impaired bacterial clearance in the absence of NOX2 ( Figure 1O )

Using modern peptide synthesis methods, researchers developed Epithalon as a defined tetrapeptide derived from peptides found in both pineal and retinal tissues.(1) Structure and Composition Epithalon is a synthetic tetrapeptide with the sequence: AlaGluAspGly (AEDG) .(2) Molecular Formula: CHNO Molecular Weight: 390.34 g/mol Other Names: Epitalon, Epithalone, AEDG peptide Epithalon is considered a key active component of Epithalamin, and pineal preparations containing Epithalon have been reported to extend lifespan in various experimental models