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The IC model was established in female Sprague-Dawley rats using cyclophosphamide injection, while the test group was injected with a mixture of cyclophosphamide and shionone solution

Perrin F, Pernier J, Bertrand O, Giard MH, Echallier JF (1987)

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It affects more than one layer of skin, and it tends to be more persistent and requires a carefully balanced approach to treat it effectively Best Ways to Get Rid of Mixed Melasma To get rid of mixed melasma, we often seek the best melasma removal cream, but dermatologists often suggest a procedure that usually involves a combination treatment, which targets both surface and deeper pigmentation