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2 Molecular architecture of anti-infective ADCs (ID-ADCs) Conventional oncology ADCs are designed around three core principles: (i) antibodies targeting tumor-associated antigens with high internalization rates, (ii) linkers cleaved under lysosomal conditions, and (iii) highly potent cytotoxic payloads that induce apoptosis in rapidly dividing host cells (Khongorzul et al., 2020)

Both MMF and fumarate are believed to be responsible for the primary therapeutic effects of DMF through activation and inhibition of the transcription factors, Nrf2 (35, 36) and Nf-B (37), respectively

Hsueh Y-J, Chen Y-N, Tsao Y-T, Cheng C-M, Wu W-C, Chen H-C (2022) The pathomechanism, antioxidant biomarkers, and treatment of oxidative stress-related eye diseases

The main sources of inconsistency in the NOS scale were sample representativeness and sample size

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