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Methotrexate has the most powerful action against the human enzyme, whereas trimethoprim is most active against the bacterial enzyme and is likely to cause megaloblastic anemia only when used in conjunction with sulfamethoxazole in patients with preexisting folate or cobalamin deficiency

If your results show low B12, we will guide you on the next steps, whether that involves dietary advice, supplementation, or a referral for further investigation

[PubMed: 12049864] 48

Discussion Results from this study indicate that a co-culture system of progenitor cells and endothelial cells can create a cord network with components found in the vasculature: endothelial cells, pericytes, and basement membrane