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Combination therapies are also employed to improve efficacy and mitigate adverse effects, for example, combining methotrexate with a biologic to reduce immunogenicity or combining phototherapy with topical treatments to achieve greater plaque clearance (Arora et al

Sudden medication changes can be dangerous

Ginsenoside rk1 induces apoptosis in neuroblastoma cells through loss of mitochondrial membrane potential and activation of caspases

Overall, limited studies investigated the improvement of pharmacological efficacy in animal models after dosing of the derivative (Table II)

The compound was first reported in Al-Obeidi, Castrucci, Hadley, and Hruby, J Med Chem 32 (12):255561 (1989) (PMID 2555512), building on the earlier open-chain superpotent precursor [Nle, D-Phe]--MSH reported by Sawyer, Sanfilippo, Hruby, Engel, Heward, Burnett, and Hadley in PNAS 77 (10):57548 (1980) (PMID 6777774)