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In addition to this risk, it is important to highlight that antidepressants such as mirtazapine (especially associated with trazodone), fluoxetine, and nortriptyline have been associated with Clostridium difficile infection in depressed patients [260]

Moreover, the complex Gel/(REG NG/LY) is formed by TGF- inhibitor LY3200882 (LY) encapsulated in ROS-responsive nanogels and homogeneously dispersed with regorafenib (REG) in a thermosensitive hydrogel can not only reduce the recruitment of TAMs and MDSCs and promote macrophages polarization from M2 to M1, but also increase the infiltration of CD8 + T cells into tumors thereby effectively inhibiting tumor growth and metastasis (213)

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Reactions were performed at 30 C for 20 min in 100 l of 50 mM sodium phosphate buffer (pH 8.0)