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After oral administration of plain glutathione, it faces multiple challenges in the gastrointestinal tract

While [1H]MRS offers the unique possibility of noninvasively measuring metabolite concentration across species, a restriction of the technique is that it measures the total concentration of metabolites, e.g., glutamate, within a selected ROI and cannot distinguish between synaptic, neuronal and glial pools

Finally, the role of polyphenols in the clinical context of IBDs, along with the main problematics regarding their translational issues and concerns will be discussed, including bioavailability, their inclusion in healthy dietary patterns and foods, interaction with other drugs, and other important points to be addressed by future research