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J Periodontol (2016) 87:e108115

J Biol Chem (2011) 286(36):318308

Moreover, iron from heme is necessary, while both Fe 2+ and Fe 3+ are sufficient to trigger ALIS formation (100)

In KRAS-mutant cancer cells with or without LKB1 loss, increased expression of SSP genes and high serine synthesis allow the cells to tolerate serine starvation for survival (Kottakis et al., 2016

These enzymes are regulated independently, thereby avoiding the risk of a futile cycle (also known as a substrate cycle) that would result if both reactions occurred simultaneously at high rates